CAS:59973-80-7Sulindac sulfone

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Sulindac sulfone inhibited K-ras-dependent COX-2 protein expression, which resulted in a decrease in prostaglandin synthase E2 production.

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

技术信息

CAS号

59973-80-7

储存条件

分子式

C20H17FO4S

运输

蓝冰

分子量

372.41

别名

溶解度

DMSO	41.0 mg/mL (110.1 mM)
Water	insoluble

动物实验配方

生物活性

描述Sulindac sulfone is a metabolite of sulindac, a non-steroidal anti-inflammatory drug (NSAID), without anti-inflammatory ability. VDAC1 and VDAC2 (voltage-dependent anion channel) are direct targets of sulindac sulfone which suppresses the mTORC1 pathway and induces G1 arrest^[1]. At 100 microMol of sulindac sulfone, a decrease in beta-catenin concentration of 5% was observed; increasing concentrations of sulindac sulfone resulted in >70% reduction in secreted beta-catenin. Sulindac sulfone reduced levels of secreted beta-catenin in the HNSCC (head and neck squamous cell carcinoma) cell line UM-SCC 11A after 48 hours of incubation^[2]. Sulindac sulfone inhibited COX-2 (cyclooxygenase) protein expression, which resulted in a decrease in prostaglandin synthase E2 production^[3]. Sulindac (20 mg/kg/day), sulindac sulfone (40 mg/kg/day), or vehicle was administered orally to male Sprague-Dawley rats for a 4-wk period beginning 20 wk after tumor induction. Sulindac and sulindac sulfone treatment significantly reduced the number and volume of colorectal tumors compared with control rats^[4].